Top Once Human Builds for PvE and PvP: Loadouts, Weapons, and Gear

In Once Human, your weapon and gear selections shape your combat prowess. Whether battling mutated creatures in PvE or clashing with rivals in PvP, a well-crafted build can mean the difference between victory and defeat.

This guide highlights four top-tier builds for the latest version of Once Human, offering in-depth details on weapons, gear modifications, synergy effects, and playstyle strategies. From area-of-effect clearing builds to damage-over-time and high-crit burst setups, these loadouts are proven effective for both solo and group play.

New to the game? Explore our Once Human Beginner’s Guide for a thorough starting point!

Key Tips for Build Optimization

Align weapon effects with mods: Select gear that amplifies your weapon’s elemental or status effects.Stay upgraded: Higher rarity and enhancement levels significantly improve performance—avoid outdated equipment.Prepare backup builds: A secondary elemental build ensures adaptability against mutant types or PvP challenges.

Each Once Human build shines in specific contexts, from boss battles and wave clearing to swift PvP eliminations. Test each loadout, refine your gear mods, and switch builds based on mission demands or enemy resistances.

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